The pharmacokinetics of phenylethyl alcohol (PEA): safety evaluation comparisons in rats, rabbits, and humans

Int J Toxicol. 2013 Jan-Feb;32(1):39-47. doi: 10.1177/1091581812471688.

Abstract

The present studies were conducted to compare the dermal absorption, plasma pharmacokinetics, and excretion of phenylethyl alcohol (PEA) by pregnant and nonpregnant rats, rabbits, and humans. The PEA is a natural fragrance material that is widely used in perfumes, soaps, and lotions and is a major ingredient of natural rose oil. Following dermal (430, 700, or 1400 mg/kg body weight [bw]), gavage (430 mg/kg bw), or dietary (430 mg/kg bw) administration of PEA to rats, plasma concentrations of PEA were found to be low regardless of the route of administration. The plasma concentrations of phenylacetic acid (PAA, the major metabolite of PEA) greatly exceeded the concentrations of PEA and were highest after gavage, followed by dermal then dietary administration. Absorption, distribution, metabolism, and excretion were compared following topical application of ¹⁴C-labeled PEA to rats, rabbits, and humans (specific activities of dosing solutions: 58-580, 164, and 50 µCi/mL, respectively). In rabbits, the plasma concentration-time profile for PAA was markedly prolonged compared to rats or humans. In humans, only 7.6% of the applied dose of PEA was absorbed, versus 77% in rats and 50% in rabbits. Based on a human dermal systemic exposure of 0.3 mg/kg per day from the use of multiple consumer personal care products containing PEA, a rat dermal no observed adverse effect level of 70 mg/kg per day, and the percentage of dose absorbed in humans, the margin of safety exceeds 2600 concluding that, under normal fragrance use conditions, PEA is not a developmental toxicity hazard for humans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Cutaneous
  • Administration, Oral
  • Adult
  • Animals
  • Consumer Product Safety
  • Dose-Response Relationship, Drug
  • Feces / chemistry
  • Female
  • Humans
  • Male
  • Metabolic Clearance Rate
  • Phenylethyl Alcohol / adverse effects*
  • Phenylethyl Alcohol / blood
  • Phenylethyl Alcohol / pharmacokinetics*
  • Phenylethyl Alcohol / urine
  • Pregnancy / blood
  • Pregnancy / metabolism*
  • Pregnancy / urine
  • Rabbits
  • Rats
  • Rats, Sprague-Dawley
  • Skin Absorption
  • Species Specificity
  • Tissue Distribution

Substances

  • Phenylethyl Alcohol